Medicinal Chemistry

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Medicinal or pharmaceutical chemistry is a scientific discipline at the intersection of chemistry and pharmacology involved with drug design, organic synthesis and developing pharmaceutical medication. Medicinal chemistry involves the identification, synthesis and development of new chemical entity suitable for therapeutic use. It also includes the study of existing drugs, their biological properties, and their quantitative structure-activity relationships (QSAR). Pharmaceutical chemistry is focused on quality aspects of medicines and aims to assure fitness for the purpose of medicinal products.

Medicinal chemistry is a highly interdisciplinary science combining organic chemistry with biochemistry, computational chemistry, pharmacology, pharmacognosy, molecular biology, statistics, and physical chemistry.

Process of drug discovery Discovery The first step of drug discovery involves the identification of new active compounds, often called "hits", which are typically found by screening many compounds for the desired biological properties. These hits can come from natural sources, such as plants, animals, or fungi. More often, the hits can come from synthetic sources, such as historical compound collections and combinatorial chemistry.

Recent developments in robotics and miniaturization have incredibly accelerated and automated the screening process. Typically, a company will assay over 100,000 individual chemical compound using a method called high-throughput screening (HTS), before moving to the optimization step.

Optimization The second step of drug discovery involves the synthetic modification of the hits in order to improve the biological properties of the compound pharmacophore. The quantitative structure-activity relationship (QSAR) of the pharmacophore play an important part in finding lead compounds, which exhibit the most potency, most selectivity, best pharmacokinetics and least toxicity. QSAR involves mainly physical chemistry and molecular docking tools (CoMFA and CoMSIA), that leads to tabulated data and first and second order equations. There are many theories, being the most relevant Hansch's analysis that involves Hammett electronic parameters, Esteric parameters and logP parameters.

See also: ADME and Lipinski's Rule of Five

Development The final step involves the rendering the lead compounds suitable for use in clinical trials. This involves the optimization of the Chemical synthesis route for bulk production, and the preparation of a suitable drug formulation.

Training in medicinal chemistry Many workers in the field do not have formal training in medicinal chemistry. Graduate (postgraduate) level programs do exist in medicinal chemistry, but frequently the broader education in a chemistry graduate program can provide many of the skills needed.

See also

Pharmacology
Pharmacognosy
Enzyme inhibitors
Galenic formulation
List of publications in chemistry#Medicinal chemistry
Pharmacophore
Pharmacodynamics
Pharmacokinetics
Pharmaceutical company

External links

Current Medicinal Chemistry
European Federation for Medicinal Chemistry
Journal of Medicinal Chemistry ( Table of Contents)

Glossary of Medicinal Chemistry
The full text of the IUPAC glossary of terms used in medicinal chemistry ... Abstract: The objective of the glossary is to provide in a single document a consistent terminology and ...

Medicinal Chemistry
Our medicinal chemistry team is fully equipped for small and large-scale synthesis (up to 100g) including microwave chemistry, combi-chem and parallel synthesis routes

Medicinal Chemistry
Information about Medicinal Chemistry Research at the Welsh School of Pharmacy at Cardiff University, Wales, UK.

Medicinal chemistry - Wikipedia, the free encyclopedia
Medicinal or pharmaceutical chemistry is a scientific discipline at the intersection of chemistry and pharmacology involved with designing, synthesizing and developing ...

IngentaConnect Publication: Medicinal Chemistry
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Librarion - Medicinal Chemistry and Compound Library Management ...
Medicinal Chemistry, Compound Synthesis and Compound Library Management

BSP :: Medicinal Chemistry Home Page
The journal for expert research articles in medicinal chemistry. ... Medicinal Chemistry aims to cover all the latest outstanding developments in medicinal ...

Medicinal Chemistry
Medicinal Chemistry: Modern laboratories and analytical facilities; Dedicated IT facilities for Medicinal Chemistry students; An enthusiastic, specialist teaching team; A ...

RGU: Medicinal Chemistry
Medicinal Chemistry ... Medicinal Chemistry . Research is undertaken in the following areas: Natural Products Chemistry. Steroid Synthesis and Photochemical oxidations. The design ...

Medicinal Chemistry at The Institute
Medicinal Chemistry at The Institute. Team Leader: Professor Julian Blagg. Location: Cancer Research UK & Haddow Laboratories, Sutton